Kusintha Maganizo a Ogula pa Ukalamba

Maganizo a ogula pankhani ya ukalamba akusintha. Malinga ndi lipoti la zomwe ogula amachitaWogula WatsopanondiCoefficient Capital, anthu ambiri aku America sakungoyang'ana kwambiri pakukhala ndi moyo wautali komanso kukhala ndi moyo wathanzi.

Kafukufuku wa McKinsey wa mu 2024 adavumbulutsa kuti chaka chathachi, 70% ya ogula ku US ndi UK (ndi 85% ku China) adagula zinthu ndi ntchito zambiri zothandizira ukalamba wathanzi komanso moyo wautali poyerekeza ndi zaka zam'mbuyomu. Kusintha kumeneku kukuwonetsa chikhumbo chowonjezeka cha ogula chofuna kulamulira thanzi lawo.

Kuphatikiza apo,Nyuzipepala ya Zamalonda ya Zakudya(NBJLipoti la 2024 la Utali wa Moyo likusonyeza kuti kuyambira mu 2022, kukula kwa malonda mu gulu la ukalamba wathanzi kwakhala kupitirira msika wonse wa zowonjezera zakudya. Mu 2023, makampani onse owonjezera zakudya adakula ndi 4.4%, pomwe gulu la ukalamba wathanzi lidakula ndi 5.5%.NBJMapulojekiti akuti kugulitsa zakudya zowonjezera thanzi—zophatikiza magulu osiyanasiyana a matenda—kudzapitirira $1 biliyoni mu 2024 ndikufika $1.04 biliyoni pofika chaka cha 2026, zomwe zikuyimira kukula kwa 7.7%.

Nkhawa za Ogula Zokhudza Mavuto a Zaumoyo Okhudzana ndi Ukalamba

AnNBJKafukufuku yemwe adachitika mu 2024 adafufuza nkhawa za ogula zokhudzana ndi ukalamba. Nkhani zazikulu zidaphatikizapo:

Kutaya kuyenda (28%)
Matenda a Alzheimer's kapena dementia (23%)
Kutaya masomphenya (23%)
Kutaya ufulu wodzilamulira (19%)
Mavuto a maganizo kapena thanzi la maganizo (19%)
Kuwonongeka kwa minofu kapena mafupa (19%)
Kutaya tsitsi (16%)
Kusowa tulo (16%)

Chithunzi chochokera: NBJ

Pogwiritsa ntchito mankhwala owonjezera, chitetezo chamthupi (35%) chinakhala nkhawa yayikulu kwambiri yokhudzana ndi thanzi la anthu okalamba. Zina zomwe zinali zofunika kwambiri zinali thanzi la m'mimba ndi m'mimba (28%), thanzi la kugona (23%), tsitsi, khungu, ndi misomali (22%), thanzi la minofu ndi mafupa (21%), thanzi la mtima (19%), ndi thanzi la maganizo (19%).

Chithunzi chochokera: NBJ

Zinthu Zisanu Zofunika Kwambiri Zoletsa Kukalamba
1. Ergothioneine

Ergothioneine ndi amino acid yopezeka mwachilengedwe yomwe idapezeka mu 1909 ndi Charles Tanret pamene ankaphunzira za bowa wa ergot. Kuchuluka kwake kwapadera kwa thiol ndi thione tautomerism pa pH ya thupi kumapatsa mphamvu zabwino kwambiri zotsutsana ndi ma antioxidants. Malinga ndi deta yochokera ku Bloomage Biotech, ergothioneine mu Bioyouth™-EGT ikuwonetsa ntchito ya DPPH yochotsa ma free radicals nthawi 14 kuposa ya glutathione ndi nthawi 30 kuposa ya coenzyme Q10.

Ubwino:

Khungu:Ergothioneine imateteza ku kutupa komwe kumabwera chifukwa cha UV, imaletsa kuwonongeka kwa DNA, komanso imalimbikitsa kupanga collagen pomwe imachepetsa kuwonongeka kwa collagen komwe kumabwera chifukwa cha UV.
Ubongo:Ergothioneine imathandizira kugwira ntchito kwa ubongo, monga momwe zasonyezedwera ndi kafukufuku wachipatala yemwe akuwonetsa kuti ubongo umakula bwino pambuyo pa milungu 12 yopatsidwa ergothioneine yochokera ku bowa.
Kugona:Imadutsa chotchinga cha magazi ndi ubongo, imachepetsa mapangidwe a peroxynitrite, ndipo imachepetsa kupsinjika maganizo, zomwe zimapangitsa kuti munthu agone bwino.

2. Spermidine

Spermidine, yomwe ndi gawo la banja la polyamine, imapezeka kwambiri m'zamoyo monga mabakiteriya, bowa, zomera, ndi nyama. Zakudya zomwe zimapezeka kwambiri ndi monga tirigu, soya, ndi bowa wa king oyster. Kuchuluka kwa spermidine kumachepa ndi ukalamba, ndipo zotsatira zake zotsutsana ndi ukalamba zimayambitsidwa ndi njira monga kuyambitsa autophagy, ntchito yotsutsana ndi kutupa, komanso kuwongolera kagayidwe ka mafuta m'thupi.

Njira:

Autophagy:Spermidine imalimbikitsa njira zobwezeretsanso maselo, pochiza matenda okhudzana ndi ukalamba okhudzana ndi zolakwika za autophagy.

Wotsutsa kutupa: Amachepetsa ma cytokines omwe amayambitsa kutupa pamene akuwonjezera zinthu zotsutsana ndi kutupa.

Kagayidwe ka Mafuta m'thupi:Spermidine imakhudza bwino kapangidwe ndi kusungidwa kwa mafuta m'thupi, imathandizira kusinthasintha kwa ma cell membrane komanso kukhala ndi moyo wautali.

3. Pyrroloquinoline Quinone (PQQ)

PQQ, quinone coenzyme yosungunuka m'madzi, ndi yofunika kwambiri pa ntchito ya mitochondrial. Imateteza ku kuwonongeka kwa mitochondrial komwe kumachitika chifukwa cha kupsinjika kwa okosijeni, imalimbikitsa biogenesis ya mitochondrial, komanso imawonjezera kupanga kwa nerve growth factor (NGF). Kafukufuku wazachipatala akuwonetsa kuti imagwira ntchito bwino pakukweza ntchito ya ubongo komanso kuyenda kwa magazi m'madera mwa okalamba.

4. Phosphatidylserine (PS)

PS ndi anionic phospholipid yomwe ili mu nembanemba ya maselo a eukaryotic, yofunikira kwambiri pa ntchito monga kuyambitsa ma enzyme, apoptosis ya maselo, ndi ntchito ya synaptic. Yochokera ku magwero monga soya, zamoyo zam'madzi, ndi mpendadzuwa, PS imathandizira machitidwe a neurotransmitter, kuphatikizapo acetylcholine ndi dopamine, zomwe zimagwirizanitsidwa ndi thanzi la chidziwitso.

Mapulogalamu:Kupatsa PS supplementation kwagwirizanitsidwa ndi kusintha kwa matenda monga Alzheimer's, Parkinson's disease, ndi depression, ndipo kumapindulitsa anthu omwe ali ndi ADHD ndi autism spectrum disorders.

5. Urolithin A (UA)

UA, yomwe ndi metabolite ya ellagitannins yomwe imapezeka muzakudya monga mapomegranate ndi walnuts, idapezeka mu 2005. Kafukufuku wofalitsidwa muMankhwala a Chilengedwe(2016) adawonetsa kuti UA imalimbikitsa mitophagy, ndikuwonjezera moyo wa mitochondria ndi 45%. Imayendetsa njira za mitochondria autophagy, kuchotsa mitochondria yowonongeka ndikuthana ndi zovuta zokhudzana ndi ukalamba mu minofu, mtima, chitetezo chamthupi, komanso thanzi la khungu.

Njira ya mitophagy yoyambitsidwa ndi UA/Chithunzi choyambira 1

Mapeto

Pamene ogula akupitirizabe kuika patsogolo thanzi ndi moyo wautali, kufunikira kwa zosakaniza zatsopano zotsutsana ndi ukalamba ndi zowonjezera kukupitirira kukwera. Zosakaniza zofunika kwambiri monga ergothioneine, spermidine, PQQ, PS, ndi UA zikutsegula njira yothetsera mavuto okhudzana ndi ukalamba. Mankhwalawa ochirikizidwa ndi sayansi akugogomezera kudzipereka kwa makampaniwa pothandizira ukalamba wathanzi komanso wamphamvu.