Kusintha Maganizo a Ogula pa Ukalamba

Malingaliro a ogula pa ukalamba akukula. Malinga ndi lipoti la ogula laWogula WatsopanondiCoefficient Capital, anthu ambiri a ku America samangoganizira za kukhala ndi moyo wautali komanso kukhala ndi moyo wathanzi.

Kafukufuku wa 2024 wa McKinsey adawonetsa kuti m'chaka chathachi, 70% ya ogula ku US ndi UK (ndi 85% ku China) agula zinthu zambiri ndi ntchito zothandizira ukalamba wathanzi ndi moyo wautali poyerekeza ndi zaka zapitazo. Kusinthaku kukuwonetsa chikhumbo chokula cha ogula chofuna kuwongolera thanzi lawo.

Kuonjezera apo,Nutrition Business Journal's(NBJ) Lipoti la 2024 Longevity Report likuwonetsa kuti kuyambira 2022, kukula kwa malonda mgulu la okalamba athanzi kwapitilira msika wokulirapo. Mu 2023, makampani opanga zowonjezera adakula ndi 4.4%, pomwe gulu lokalamba lathanzi lidapeza kukula kwa 5.5%.NBJmapulojekiti omwe kugulitsa zakudya zopatsa thanzi zaukalamba - kutengera magawo osiyanasiyana okhudzana ndi chikhalidwe - kupitilira $ 1 biliyoni mu 2024 ndikufikira $ 1.04 biliyoni pofika 2026, zomwe zikuyimira kukula kwa 7.7%.

Nkhawa za Ogula Pankhani Zaumoyo Zokhudzana ndi Zaka

AnNBJKafukufuku yemwe adachitika mu 2024 adawunikira nkhawa za ogula zokhudzana ndi ukalamba. Nkhani zazikulu zinalipo:

Kulephera kuyenda (28%)
Matenda a Alzheimer's kapena dementia (23%)
Kutaya masomphenya (23%)
Kutaya ufulu wodzilamulira (19%)
Mavuto amalingaliro kapena malingaliro (19%)
Kuwonongeka kwa minofu kapena chigoba (19%)
Kutayika tsitsi (16%)
Kusowa tulo (16%)

Chithunzi chojambula: NBJ

Mukamagwiritsa ntchito zowonjezera, chitetezo chamthupi (35%) chidawoneka ngati chofunikira kwambiri chokhudzana ndi ukalamba kwa ogula. Zina zofunika kwambiri zimaphatikizapo thanzi la m'matumbo ndi m'mimba (28%), thanzi la kugona (23%), tsitsi, khungu, ndi misomali (22%), thanzi la minofu ndi mafupa (21%), thanzi la mtima (19%), ndi maganizo abwino (19%).

Chithunzi chojambula: NBJ

Zosakaniza Zisanu Zotsutsa Kukalamba
1. Ergothioneine

Ergothioneine ndi amino acid yopezeka mwachilengedwe yomwe idapezeka mu 1909 ndi Charles Tanret pophunzira bowa wa ergot. Ma thiol ndi thione tautomerism pa physiological pH amamupatsa mawonekedwe apadera a antioxidant. Malinga ndi data yochokera ku Bloomage Biotech, ergothioneine mu Bioyouth™-EGT imawonetsa DPPH yaulere yowononga kwambiri nthawi 14 kuposa ya glutathione ndi nthawi 30 ya coenzyme Q10.

Ubwino:

Khungu:Ergothioneine imateteza ku kutupa kwa UV, imalepheretsa kuwonongeka kwa DNA, ndikulimbikitsa kaphatikizidwe ka collagen ndikuchepetsa kuwonongeka kwa kolajeni komwe kumakhudzana ndi UV.
Ubongo:Ergothioneine imathandizira chidziwitso, monga umboni wa kafukufuku wachipatala wosonyeza kuzindikira bwino pambuyo pa masabata a 12 owonjezera ndi ergothioneine yotengedwa ndi bowa.
Gona:Amadutsa chotchinga cha magazi-ubongo, amachepetsa mapangidwe a peroxynitrite, komanso amachepetsa nkhawa, amalimbikitsa kugona bwino.

2. Spermidine

Spermidine, mbali ya banja la polyamine, imapezeka kwambiri mu zamoyo monga mabakiteriya, bowa, zomera, ndi nyama. Zakudya zodziwika bwino zimaphatikizapo nyongolosi ya tirigu, soya, ndi bowa wa oyster. Miyezo ya Spermidine imatsika ndi ukalamba, ndipo zotsatira zake zotsutsana ndi ukalamba zimachitika chifukwa cha njira monga autophagy induction, anti-inflammatory action, and lipid metabolism regulation.

Njira:

Autophagy:Spermidine imalimbikitsa njira zobwezeretsanso ma cell, kuthana ndi matenda okhudzana ndi ukalamba omwe amalumikizidwa ndi vuto la autophagy.

Anti-kutupa: Amachepetsa ma cytokines oyambitsa kutupa pomwe akuwonjezera zinthu zotsutsana ndi zotupa.

Lipid Metabolism:Spermidine imakhudza kaphatikizidwe ndi kusungidwa kwa lipid, kumathandizira kusungunuka kwa membrane wam'manja ndi moyo wautali.

3. Pyrroloquinoline Quinone (PQQ)

PQQ, quinone coenzyme yosungunuka m'madzi, ndiyofunikira pakugwira ntchito kwa mitochondrial. Zimateteza kuwonongeka kwa mitochondrial kupsinjika kwa okosijeni, kumalimbikitsa biogenesis ya mitochondrial, ndikuwonjezera kupanga kwa mitsempha ya kukula kwa mitsempha (NGF). Kafukufuku wachipatala akuwonetsa mphamvu zake pakuwongolera magwiridwe antchito anzeru komanso kuyenda kwa magazi m'dera mwa okalamba.

4. Phosphatidylserine (PS)

PS ndi anionic phospholipid mu nembanemba ya eukaryotic cell, yofunikira pamachitidwe monga kuyambitsa ma enzyme, cell apoptosis, ndi synaptic function. Kuchokera ku magwero monga soya, zamoyo zam'madzi, ndi mpendadzuwa, PS imathandizira machitidwe a neurotransmitter, kuphatikizapo acetylcholine ndi dopamine, omwe amagwirizanitsidwa ndi thanzi labwino.

Mapulogalamu:PS supplementation yalumikizidwa ndi kusintha kwa mikhalidwe monga Alzheimer's, Parkinson's disease, and depression, ndipo imapindulitsa anthu omwe ali ndi ADHD ndi autism spectrum disorders.

5. Urolithin A (UA)

UA, metabolite ya ellagitannins yomwe imapezeka muzakudya monga makangaza ndi mtedza, idadziwika mu 2005.Natural Medicine(2016) adawonetsa kuti UA imalimbikitsa mitophagy, kukulitsa moyo wa nematodes ndi 45%. Imayendetsa njira za mitochondrial autophagy, kuchotsa mitochondria yowonongeka ndikuthana ndi zovuta zokhudzana ndi ukalamba mu minofu, mtima, chitetezo cha mthupi, komanso thanzi la khungu.

UA activated mitophagy pathway/Image source reference 1

Mapeto

Pamene ogula amaika patsogolo thanzi ndi moyo wautali, kufunikira kwa zosakaniza zotsutsana ndi ukalamba ndi zowonjezera zikuwonjezeka. Zosakaniza zazikulu monga ergothioneine, spermidine, PQQ, PS, ndi UA zikupereka njira zothetsera nkhawa zokhudzana ndi zaka. Mankhwala ochirikizidwa ndi asayansiwa amatsimikizira kudzipereka kwamakampani kuti athandizire kukalamba bwino komanso kosangalatsa.