M'zaka zaposachedwapa, vuto la kunenepa kwambiri padziko lonse lapansi lakhala likukulirakulira.

M'zaka zaposachedwapa, vuto la kunenepa kwambiri padziko lonse lapansi lakhala lalikulu kwambiri. Malinga ndi "Global Obesity Atlas 2025" yomwe idatulutsidwa ndi World Obesity Federation, chiwerengero chonse cha akuluakulu onenepa padziko lonse lapansi chikuyembekezeka kuwonjezeka kuchoka pa 524 miliyoni mu 2010 kufika pa 1.13 biliyoni mu 2030, kuwonjezeka kwa oposa 115%. Potengera izi, chiwerengero chowonjezeka cha ogula chikufuna zosakaniza zachilengedwe zomwe zingathandize kupewa kunenepa kwambiri. Mu June chaka chino, kafukufuku wofalitsidwa mu magazini ya "npj science of food" adawonetsa kuti curcumin imachepetsa kuchulukana kwa mafuta m'mimba mwa makoswe a MASH poletsa kutulutsidwa kwa ma polypeptides oletsa gastric inhibitory (GIP) omwe amayamba chifukwa cha kuvulala kwa m'mimba komwe kumachepa. Kupeza kumeneku sikungopereka malingaliro atsopano oletsa kunenepa kwambiri komanso kumakulitsa msika wogwiritsira ntchito curcumin.

Kodi curcumin imaletsa bwanji kusonkhanitsa mafuta m'thupi? Kusonkhanitsa mafuta m'thupi kumatanthauza kusonkhanitsa mafuta mopitirira muyeso kapena mopitirira muyeso. Zakudya zokhala ndi chakudya chambiri, mafuta ambiri komanso kusachita masewera olimbitsa thupi zonse zingayambitse kusalingana kwa mphamvu, zomwe zimapangitsa kuti mafuta m'thupi azikhala ochulukirapo. Njira ya m'mimba ndi gawo lofunika kwambiri poyamwa mafuta. Kusonkhanitsa mafuta m'thupi ndi gawo lofunika kwambiri la steatohepatitis (MASH) yomwe imayambitsa matenda a kagayidwe kachakudya. Malinga ndi kafukufukuyu, curcumin ndi maantibayotiki zimatha kuchepetsa kulemera kwa thupi la makoswe a MASH, ndipo curcumin ndi maantibayotiki zimakhala ndi mphamvu yogwirizana.

Kafukufuku wa njira wapeza kuti curcumin imachepetsa kwambiri kulemera kwa mafuta a m'mimba, makamaka m'minofu ya perirenal. Curcumin imaletsa kulemera mwa kuletsa kutulutsidwa kwa GIP ndikuchepetsa index ya minofu ya adipose yozungulira impso. Kuchepetsa kutulutsidwa kwa GIP m'matumbo chifukwa cha curcumin kumaletsa kuyambika kwa ma receptors a GIP, motero kuchepetsa adipogenesis ndi kutupa m'minofu ya perirenal adipose. Kuphatikiza apo, curcumin imatha kuchepetsa hypoxia ya m'matumbo ang'onoang'ono poteteza epithelium ya m'matumbo ndi chotchinga cha mitsempha yamagazi, motero kuchepetsa kutulutsidwa kwa GIP. Pomaliza, zotsatira za curcumin pa mafuta a m'mimba makamaka zimafooketsa kutulutsidwa kwa GIP poletsa hypoxia yomwe imayambitsidwa ndi kusokonezeka kwa chotchinga cha m'matumbo.

Curcumin, "katswiri wotsutsa kutupa", makamaka amachokera ku mizu ndi mizu ya Curcuma (Curcuma longa L.). Ndi mankhwala a polyphenolic otsika kwambiri ndipo nthawi zambiri amagwiritsidwa ntchito ngati zokometsera muzakudya zosiyanasiyana. Mu 1815, Vegel et al. adalemba koyamba za kuchotsedwa kwa "mankhwala achikasu a lalanje" kuchokera ku mizu ya turmeric ndipo adatcha curcumin. Mpaka mu 1910, Kazimierz ndi asayansi ena adazindikira kapangidwe kake ka mankhwala kukhala diferulic acylmethane. Umboni womwe ulipo ukusonyeza kuti curcumin ili ndi mphamvu yotsutsa kutupa. Imatha kukhala ndi mphamvu yotsutsa kutupa mwa kuletsa njira ya Toll-like receptor 4 (TLR4) ndi njira yake yolumikizira ya nuclear factor kB (NF-kB), ndikuchepetsa kupanga zinthu zomwe zimayambitsa kutupa monga interleukin-1 β(IL-1β) ndi tumor necrosis factor -α(TNF-α). Pakadali pano, mphamvu zake zotsutsana ndi kutupa zimaonedwa ngati maziko a ntchito zosiyanasiyana zamoyo, ndipo kafukufuku wambiri woyambirira kapena wachipatala wafufuza momwe zimagwirira ntchito pa matenda otupa. Pakati pawo, matenda otupa m'matumbo, nyamakazi, psoriasis, kuvutika maganizo, atherosclerosis ndi COVID-19 ndi madera ofufuza otchuka kwambiri pakadali pano.

Chifukwa cha chitukuko cha msika wamakono, curcumin ndi yovuta kupeza mlingo woyenera kudzera mu zakudya zokha ndipo imafunika kutengedwa ngati zowonjezera. Chifukwa chake, yakula kwambiri m'magawo azakudya zopatsa thanzi komanso zowonjezera zakudya.

Justgood Health yapanganso mitundu yosiyanasiyana ya ma supplements a curcumin gummy ndi ma capsules a curcumin. Makampani ambiri ogulitsa asintha mlingo kapena mawonekedwe a mtundu wawo.

Kafukufuku wowonjezera pa ubwino wa curcumin wapeza kuti curcumin sikuti imangothandiza kukana kunenepa kwambiri komanso imakhala ndi zotsatira zambiri monga antioxidation, neuroprotection, relieve of pain of bones and support for cardiovascular health. Antioxidant: Kafukufuku wapeza kuti curcumin imatha kuchotsa mwachindunji ma free radicals ndikuwonjezera ntchito ya mitochondrial poyambitsa njira monga kuletsa mapuloteni olamulira 3 (SIRT3), motero kuchepetsa kupanga mitundu yambiri ya okosijeni (ROS) kuchokera ku gwero ndikuchepetsa kuwonongeka kwa okosijeni m'maselo. Neuroprotection: Umboni wofufuza womwe ulipo ukusonyeza kuti kutupa kumagwirizana kwambiri ndi kuvutika maganizo. Curcumin ikhoza kukonza zizindikiro za kukhumudwa komanso nkhawa za odwala omwe ali ndi kuvutika maganizo. Curcumin ingathandize kukana kuwonongeka kwa mitsempha chifukwa cha interleukin-1 β (IL-1β) ndi zinthu zina, ndikuchepetsa machitidwe ofanana ndi kupsinjika maganizo omwe amayamba chifukwa cha kupsinjika maganizo kosatha. Chifukwa chake, ikhoza kukhala ndi gawo labwino pothandizira thanzi la ubongo ndi kuwongolera malingaliro. Kuchepetsa ululu wa minofu ndi mafupa: Kafukufuku wasonyeza kuti curcumin imatha kukonza zizindikiro zachipatala za nyama zamtundu wa nyamakazi ndikuteteza minofu ndi mafupa pochepetsa kutupa. Curcumin imatha kuchepetsa ululu wa minofu ndi mafupa chifukwa imatha kuletsa kwambiri kutulutsidwa kwa zinthu zomwe zimayambitsa kutupa monga chotupa necrosis factor -α (TNF-α) ndi interleukin-1 β (IL-1β), kuchepetsa kutupa komwe kumachitika m'malo mwake, motero kuchepetsa zizindikiro za kutupa ndi kupweteka kwa mafupa. Kuthandizira thanzi la mtima: Ponena za dongosolo la mtima, curcumin imatha kugwira ntchito powongolera mafuta m'magazi, kuchepetsa cholesterol yonse m'magazi, triglycerides ndi cholesterol yotsika kwambiri, pomwe ikuwonjezera cholesterol yotsika kwambiri. Kuphatikiza apo, curcumin imathanso kuletsa kuchuluka kwa maselo osalala a minofu ndi kutupa, zomwe zimathandiza popewa kufalikira kwa matenda amtima monga atherosclerosis.