Astaxanthin (3,3'-dihydroxy-beta, beta-carotene-4,4'-dione) ndi carotenoid, yomwe ili m'gulu la lutein, yomwe imapezeka m'mitundu yosiyanasiyana ya tizilombo toyambitsa matenda ndi nyama zam'madzi, ndipo poyamba inachotsedwa ku nkhanu ndi Kuhn ndi Sorensen. Ndi utoto wosungunuka ndi mafuta womwe umawoneka ngati lalanje mpaka wofiira kwambiri ndipo ulibe vitamini A pro-activity m'thupi la munthu.
Magwero achilengedwe a astaxanthin ndi algae, yisiti, salimoni, trout, krill ndi crayfish. Astaxanthin yogulitsa imachokera makamaka ku yisiti ya Fife, algae wofiira ndi kapangidwe ka mankhwala. Chimodzi mwa magwero abwino kwambiri a astaxanthin yachilengedwe ndi chlorella yofiira yodyetsedwa ndi mvula, yokhala ndi astaxanthin pafupifupi 3.8% (ndi kulemera kouma), ndipo salimoni wakuthengo nawonso ndi magwero abwino a astaxanthin. Kupanga kwachilengedwe ndiko gwero lalikulu la astaxanthin chifukwa cha mtengo wokwera wa kulima kwakukulu kwa Rhodococcus rainieri. Ntchito yachilengedwe ya astaxanthin yopangidwa ndi kapangidwe ndi 50% yokha ya astaxanthin yachilengedwe.
Astaxanthin ilipo ngati stereoisomers, geometric isomers, mawonekedwe aulere komanso okhazikika, ndipo stereoisomers (3S,3'S) ndi (3R,3'R) ndizo zambiri mwachilengedwe. Rhodococcus rainieri imapanga (3S,3'S)-isomer ndipo yisiti ya Fife imapanga (3R,3'R)-isomer.
Astaxanthin, kutentha kwa nthawi ino
Astaxanthin ndiye chinthu chofunika kwambiri muzakudya zogwira ntchito ku Japan. Ziwerengero za FTA pazazidziwitso zazakudya zogwira ntchito ku Japan mu 2022 zidapeza kuti astaxanthin inali pa nambala 7 pakati pa zosakaniza 10 zapamwamba pankhani yogwiritsidwa ntchito pafupipafupi, ndipo idagwiritsidwa ntchito kwambiri m'magawo azaumoyo monga chisamaliro cha khungu, chisamaliro cha maso, kuchepetsa kutopa, komanso kukonza magwiridwe antchito a ubongo.
Pa Mphotho za Zakudya Zaku Asia za 2022 ndi 2023,Thanzi la Justgood Chosakaniza chachilengedwe cha astaxanthin chinadziwika ngati chosakaniza chabwino kwambiri chaka chino kwa zaka ziwiri zotsatizana, chosakaniza chabwino kwambiri mu njira yogwirira ntchito ya chidziwitso mu 2022, komanso chosakaniza chabwino kwambiri mu njira yokongola ya pakamwa mu 2023. Kuphatikiza apo, chosakanizacho chinasankhidwa mu nyimbo ya Asian Nutritional Ingredients Awards - Healthy Aging mu 2024.
M'zaka zaposachedwapa, kafukufuku wamaphunziro pa astaxanthin wayambanso kutentha. Malinga ndi deta ya PubMed, kuyambira mu 1948, panali maphunziro pa astaxanthin, koma chidwi chakhala chochepa, kuyambira mu 2011, masukulu apamwamba anayamba kuyang'ana kwambiri pa astaxanthin, ndi mabuku opitilira 100 pachaka, ndi opitilira 200 mu 2017, opitilira 300 mu 2020, ndi opitilira 400 mu 2021.
Chithunzicho chili ndi: PubMed
Ponena za msika, malinga ndi chidziwitso cha msika wa Future, kukula kwa msika wa astaxanthin padziko lonse lapansi kukuyembekezeka kukhala USD 273.2 miliyoni mu 2024 ndipo akuyembekezeka kufika USD 665.0 miliyoni pofika chaka cha 2034, pa CAGR ya 9.3% panthawi yolosera (2024-2034).
Mphamvu yapamwamba kwambiri ya antioxidant
Kapangidwe kake kapadera ka Astaxanthin kamapatsa mphamvu yabwino kwambiri yolimbana ndi ma antioxidants. Astaxanthin ili ndi ma conjugated double bonds, magulu a hydroxyl ndi ketone, ndipo imakonda lipophilic komanso hydrophilic. Conjugated double bond yomwe ili pakati pa mankhwalawa imapereka ma elekitironi ndipo imachitapo kanthu ndi ma free radicals kuti iwasinthe kukhala zinthu zokhazikika komanso kuthetsa ma free radical chain reactions m'zamoyo zosiyanasiyana. Ntchito yake yachilengedwe ndi yapamwamba kuposa ya ma antioxidants ena chifukwa cha kuthekera kwake kulumikizana ndi nembanemba ya maselo kuchokera mkati kupita kunja.
Malo a astaxanthin ndi ma antioxidants ena m'maselo a maselo
Astaxanthin imagwira ntchito yofunika kwambiri yolimbana ndi ma antioxidants osati kokha mwa kuchotsa mwachindunji ma free radicals, komanso kudzera mu kuyambitsa chitetezo cha ma cell antioxidant system mwa kuwongolera njira ya nuclear factor erythroid 2-related factor (Nrf2). Astaxanthin imaletsa kupangidwa kwa ROS ndikulamulira kuwonetsedwa kwa ma enzymes ogwirizana ndi kupsinjika kwa okosijeni, monga heme oxygenase-1 (HO-1), yomwe ndi chizindikiro cha kupsinjika kwa okosijeni.HO-1 imayendetsedwa ndi zinthu zosiyanasiyana zomwe zimakhudzidwa ndi kupsinjika, kuphatikiza Nrf2, yomwe imagwirizana ndi zinthu zomwe zimakhudzidwa ndi antioxidant m'dera lothandizira ma enzymes a metabolism.
Ubwino wonse wa astaxanthin ndi ntchito zake
1) Kupititsa patsogolo ntchito ya chidziwitso
Kafukufuku wambiri watsimikizira kuti astaxanthin ikhoza kuchedwetsa kapena kusintha kusowa kwa chidziwitso komwe kumakhudzana ndi ukalamba wabwinobwino kapena kuchepetsa matenda osiyanasiyana a neurodegenerative. Astaxanthin imatha kudutsa chotchinga cha magazi ndi ubongo, ndipo kafukufuku wasonyeza kuti astaxanthin yazakudya imasonkhana mu hippocampus ndi cerebral cortex ya ubongo wa makoswe atadya kamodzi kapena mobwerezabwereza, zomwe zingakhudze kusunga ndi kukonza magwiridwe antchito a chidziwitso. Astaxanthin imalimbikitsa kukonzanso kwa maselo amitsempha ndikuwonjezera kufotokozera kwa majini a glial fibrillary acidic protein (GFAP), microtubule-associated protein 2 (MAP-2), brain-derived neurotrophic factor (BDNF), ndi growth-associated protein 43 (GAP-43), mapuloteni omwe amakhudzidwa ndi kuchira kwa ubongo.
Ma Capsule a Justgood Health Astaxanthin, okhala ndi Cytisine ndi Astaxanthin ochokera ku Red Algae Rainforest, amagwira ntchito limodzi kuti ubongo uzigwira bwino ntchito yake.
2) Chitetezo cha Maso
Astaxanthin ili ndi mphamvu yoletsa ma molecule a oxygen free radicals ndipo imateteza maso. Astaxanthin imagwira ntchito mogwirizana ndi ma carotenoids ena omwe amathandizira thanzi la maso, makamaka lutein ndi zeaxanthin. Kuphatikiza apo, astaxanthin imawonjezera kuthamanga kwa magazi kupita ku maso, zomwe zimathandiza magazi kubwezeretsanso mpweya mu retina ndi minofu ya maso. Kafukufuku wasonyeza kuti astaxanthin, pamodzi ndi ma carotenoids ena, amateteza maso ku kuwonongeka kwa dzuwa lonse. Kuphatikiza apo, astaxanthin imathandiza kuchepetsa kusasangalala kwa maso komanso kutopa kwa maso.
Ma Softgels a Justgood Health Blue Light Protection, Zosakaniza zofunika: lutein, zeaxanthin, astaxanthin.
3) Kusamalira Khungu
Kupsinjika kwa okosijeni ndi chinthu chofunikira kwambiri chomwe chimayambitsa kukalamba kwa khungu la munthu komanso kuwonongeka kwa khungu. Njira yomwe imayambira mkati (nthawi) komanso kunja (kupepuka) imayambira pakupanga ROS, kudzera mu kagayidwe ka okosijeni, komanso kunja kwa khungu kudzera mu kuwala kwa ultraviolet (UV). Zochitika zomwe zimapangitsa kuti khungu lizikula ndi monga kuwonongeka kwa DNA, kutupa, kuchepetsa ma antioxidants, komanso kupanga matrix metalloproteinases (MMPs) zomwe zimawononga collagen ndi elastin m'dermis.
Astaxanthin imatha kuletsa kuwonongeka kwa okosijeni komwe kumachitika chifukwa cha ma free radicals komanso kuyambitsa kwa MMP-1 pakhungu pambuyo pa kuwala kwa UV. Kafukufuku wasonyeza kuti astaxanthin yochokera ku Erythrocystis rainbowensis imatha kuwonjezera kuchuluka kwa collagen mwa kuletsa kuwonekera kwa MMP-1 ndi MMP-3 mu ma fibroblast a khungu la munthu. Kuphatikiza apo, astaxanthin inachepetsa kuwonongeka kwa DNA komwe kumachitika chifukwa cha UV komanso inawonjezera kukonzanso kwa DNA m'maselo omwe ali ndi kuwala kwa UV.
Pakadali pano Justgood Health ikuchita maphunziro angapo, kuphatikizapo makoswe opanda ubweya ndi mayeso a anthu, omwe onse asonyeza kuti astaxanthin imachepetsa kuwonongeka kwa UV ku zigawo zakuya za khungu, zomwe zimayambitsa kuwoneka kwa zizindikiro za ukalamba wa khungu, monga kuuma, khungu lofooka ndi makwinya.
4) Zakudya zamasewera
Astaxanthin imatha kufulumizitsa kukonzanso pambuyo pa masewera olimbitsa thupi. Anthu akamachita masewera olimbitsa thupi kapena kuchita masewera olimbitsa thupi, thupi limapanga ROS yambiri, yomwe, ngati sichotsedwa pa nthawi yake, ingawononge minofu ndikukhudza kuchira kwa thupi, pomwe ntchito yamphamvu ya astaxanthin yolimbana ndi ma antioxidants imatha kuchotsa ROS pa nthawi yake ndikukonzanso minofu yowonongeka mwachangu.
Justgood Health yayambitsa Astaxanthin Complex yake yatsopano, yosakaniza mitundu yambiri ya magnesium glycerophosphate, vitamini B6 (pyridoxine), ndi astaxanthin yomwe imachepetsa kupweteka kwa minofu ndi kutopa pambuyo pochita masewera olimbitsa thupi. Fomula iyi imayang'ana pa Whole Algae Complex ya Justgood Health, yomwe imapereka astaxanthin yachilengedwe yomwe sikuti imateteza minofu ku kuwonongeka kwa okosijeni, komanso imawonjezera magwiridwe antchito a minofu ndikuwonjezera magwiridwe antchito amasewera.
5) Thanzi la Mtima ndi Mitsempha
Kupsinjika kwa okosijeni ndi kutupa ndizomwe zimayambitsa matenda a mtima ndi mitsempha yamagazi. Mphamvu yabwino kwambiri ya astaxanthin yoteteza ku matenda a mtima imatha kupewa ndikuwonjezera atherosclerosis.
Ma Softgel a Justgood Health Triple Strength Natural Astaxanthin Softgels amathandiza kukhala ndi thanzi la mtima pogwiritsa ntchito astaxanthin yachilengedwe yochokera ku algae yofiira ya utawaleza, zomwe zimaphatikizapo astaxanthin, mafuta a kokonati achilengedwe ndi ma tocopherols achilengedwe.
6) Kulamulira chitetezo cha mthupi
Maselo a chitetezo chamthupi amakhala okhudzidwa kwambiri ndi kuwonongeka kwa ma free radicals. Astaxanthin imateteza chitetezo cha chitetezo chamthupi popewa kuwonongeka kwa ma free radicals. Kafukufuku adapeza kuti astaxanthin m'maselo a anthu kuti apange ma immunoglobulins, m'thupi la munthu astaxanthin yowonjezera kwa milungu 8, kuchuluka kwa astaxanthin m'magazi kumawonjezeka, maselo a T ndi maselo a B kumawonjezeka, kuwonongeka kwa DNA kumachepa, mapuloteni a C-reactive amachepa kwambiri.
Ma astaxanthin softgels, astaxanthin wosaphika, amagwiritsa ntchito kuwala kwa dzuwa, madzi osefedwa ndi lava ndi mphamvu ya dzuwa kuti apange astaxanthin yoyera komanso yathanzi, yomwe ingathandize kulimbitsa chitetezo cha mthupi, kuteteza masomphenya ndi thanzi la mafupa.
7) Kuchepetsa Kutopa
Kafukufuku wa milungu inayi wochitidwa mwachisawawa, wosawoneka bwino, wolamulidwa ndi placebo, komanso wochitidwa m'njira ziwiri, adapeza kuti astaxanthin imathandizira kuchira ku kutopa kwamisala komwe kumabwera chifukwa cha Visual display terminal (VDT), zomwe zimapangitsa kuti milingo ya phosphatidylcholine hydroperoxide (PCOOH) ikwere kwambiri panthawi yonse ya masewera olimbitsa thupi komanso amisala. Chifukwa chake chingakhale ntchito ya astaxanthin yoletsa kutupa komanso njira yoletsa kutupa.
8) Chitetezo cha chiwindi
Astaxanthin ili ndi zotsatira zoteteza komanso zochepetsera mavuto azaumoyo monga fibrosis ya chiwindi, kuvulala kwa ischemia-reperfusion ya chiwindi, ndi NAFLD. Astaxanthin imatha kuwongolera njira zosiyanasiyana zolumikizirana, monga kuchepetsa ntchito ya JNK ndi ERK-1 kuti iwonjezere kukana kwa insulin m'chiwindi, kuletsa kufalikira kwa PPAR-γ kuti ichepetse kupanga mafuta m'chiwindi, komanso kuchepetsa kufalikira kwa TGF-β1/Smad3 kuti ilepheretse kuyambika kwa HSCs ndi fibrosis ya chiwindi.
Mkhalidwe wa malamulo m'dziko lililonse
Ku China,astaxanthin Kuchokera ku gwero la algae wofiira wa utawaleza kungagwiritsidwe ntchito ngati chosakaniza chatsopano cha chakudya mu chakudya chambiri (kupatula chakudya cha ana), kuphatikiza apo, United States, Canada ndi Japan amalolanso astaxanthin kugwiritsidwa ntchito mu chakudya.
Nthawi yotumizira: Disembala-05-2024