Astaxanthin (3,3'-dihydroxy-beta,beta-carotene-4,4'-dione) ndi carotenoid, yodziwika ngati lutein, yomwe imapezeka mumitundu yosiyanasiyana ya tizilombo tating'onoting'ono ndi nyama zam'madzi, ndipo poyamba idalekanitsidwa ndi nkhanu ndi Kuhn ndi Sorensen. Ndi pigment yosungunuka mafuta yomwe imawoneka ngati lalanje mpaka yofiira kwambiri ndipo ilibe vitamini A yogwira ntchito m'thupi la munthu.
Magwero achilengedwe a astaxanthin amaphatikizapo algae, yisiti, salimoni, trout, krill ndi crayfish. Astaxanthin yamalonda imachokera ku yisiti ya Fife, algae wofiira ndi kaphatikizidwe ka mankhwala. Chimodzi mwazinthu zabwino kwambiri za astaxanthin zachilengedwe ndi chlorella yofiira yamvula, yokhala ndi astaxanthin pafupifupi 3.8% (mwa kulemera kowuma), komanso nsomba zakuthengo nazonso zimakhala zabwino za astaxanthin. Kupanga kopanga akadali gwero lalikulu la astaxanthin chifukwa cha kukwera mtengo kwa kulima kwakukulu kwa Rhodococcus rainieri. Ntchito yachilengedwe ya astaxanthin yopangidwa mwaluso ndi 50% yokha ya astaxanthin yachilengedwe.
Astaxanthin ilipo ngati stereoisomers, geometric isomers, free and esterified forms, ndi stereoisomers (3S,3'S) ndi (3R,3'R) kukhala ochuluka kwambiri m'chilengedwe. Rhodococcus rainieri imapanga (3S,3'S) -isomer ndi Fife yeast imapanga (3R,3'R) -isomer.
Astaxanthin, kutentha kwa mphindi
Astaxanthin ndiye gawo lalikulu lazakudya zomwe zimagwira ntchito ku Japan.Ziwerengero za FTA pazolengeza chakudya chogwira ntchito ku Japan mu 2022 zidapeza kuti astaxanthin idayikidwa pa nambala 7 pakati pa zosakaniza 10 zomwe zimagwiritsidwa ntchito pafupipafupi, ndipo zidagwiritsidwa ntchito makamaka pazaumoyo wa chisamaliro cha khungu, chisamaliro cha maso, mpumulo wa kutopa, ndi kusintha kwa ntchito ya chidziwitso.
Pampikisano wa 2022 ndi 2023 Asian Nutritional Ingredients Awards, zosakaniza zachilengedwe za Justgood Health za astaxanthin zidadziwika kuti ndizofunikira kwambiri pachaka kwa zaka ziwiri zotsatizana, zomwe zili bwino kwambiri pazidziwitso zantchito mu 2022, komanso chothandizira chabwino kwambiri panjira yokongola yapakamwa. 2023. Kuphatikiza apo, chophatikiziracho chinalembedwa mwachidule mu Asian Nutritional Ingredients Awards - Healthy Aging track mu 2024.
M'zaka zaposachedwa, kafukufuku wamaphunziro a astaxanthin wayambanso kutentha. Malinga ndi data ya PubMed, koyambirira kwa 1948, panali maphunziro a astaxanthin, koma chidwi chakhala chochepa, kuyambira mu 2011, maphunziro adayamba kuyang'ana pa astaxanthin, ndi zofalitsa zopitilira 100 pachaka, komanso zopitilira 200 mu 2017, zochulukirapo. kuposa 300 mu 2020, ndi oposa 400 mu 2021.
Gwero la chithunzi:PubMed
Pankhani ya msika, malinga ndi zidziwitso za msika wamtsogolo, kukula kwa msika wa astaxanthin padziko lonse lapansi kukuyembekezeka kukhala $ 273.2 miliyoni mu 2024 ndipo akuyembekezeka kufika $ 665.0 miliyoni pofika 2034, pa CAGR ya 9.3% panthawi yolosera (2024-2034) ).
Mphamvu yapamwamba ya antioxidant
Mapangidwe apadera a Astaxanthin amamupatsa mphamvu ya antioxidant. Astaxanthin ili ndi ma conjugated double bond, hydroxyl ndi ketone magulu, ndipo onse ndi lipophilic ndi hydrophilic. The conjugated double bond pakatikati pa pawiri amapereka ma elekitironi ndi amachita ndi ma radicals ufulu kuwasandutsa zinthu khola kwambiri ndi kuthetseratu ufulu ankafuna kusintha chain zochita mu zamoyo zosiyanasiyana. Ntchito yake yachilengedwe ndiyopambana kuposa ya ma antioxidants ena chifukwa chotha kulumikizana ndi nembanemba zama cell kuchokera mkati kupita kunja.
Malo a astaxanthin ndi ma antioxidants ena m'maselo a cell
Astaxanthin imakhala ndi ntchito yayikulu yoteteza antioxidant osati kungowononga mwachindunji ma radicals aulere, komanso kudzera mu kuyambitsa ma cell antioxidant system powongolera njira ya nyukiliya erythroid 2-related factor (Nrf2). Astaxanthin imalepheretsa mapangidwe a ROS ndikuwongolera mawonetseredwe a ma enzymes omwe amakhudzidwa ndi okosijeni, monga heme oxygenase-1 (HO-1), yomwe ndi chizindikiro cha kupsinjika kwa okosijeni.HO-1 imayendetsedwa ndi zolembedwa zosiyanasiyana zosavutikira. zinthu, kuphatikizapo Nrf2, zomwe zimamangiriza ku zinthu zotsutsana ndi antioxidant m'dera lolimbikitsa la detoxification metabolism enzymes.
Ubwino wathunthu wa astaxanthin ndi kugwiritsa ntchito
1) Kupititsa patsogolo chidziwitso cha ntchito
Kafukufuku wambiri watsimikizira kuti astaxanthin imatha kuchedwetsa kapena kuwongolera kuperewera kwachidziwitso komwe kumayenderana ndi ukalamba wabwinobwino kapena kuchepetsa ma pathophysiology amatenda osiyanasiyana a neurodegenerative. Astaxanthin imatha kuwoloka chotchinga chamagazi-muubongo, ndipo kafukufuku wasonyeza kuti zakudya za astaxanthin zimadziunjikira mu hippocampus ndi cerebral cortex ya ubongo wa makoswe pambuyo podya kamodzi komanso mobwerezabwereza, zomwe zingakhudze kukonza ndi kuwongolera kwa chidziwitso. Astaxanthin imalimbikitsa kusinthika kwa mitsempha ya mitsempha ndikuwonjezera jini ya glial fibrillary acidic protein (GFAP), mapuloteni ogwirizana ndi microtubule 2 (MAP-2), ubongo-derived neurotrophic factor (BDNF), ndi mapuloteni okhudzana ndi kukula 43 (GAP-43), mapuloteni omwe amakhudzidwa ndi kuchira kwa ubongo.
Makapisozi a Justgood Health Astaxanthin, okhala ndi Cytisine ndi Astaxanthin ochokera ku Red Algae Rainforest, amalumikizana kuti apititse patsogolo kuzindikira kwa ubongo.
2) Chitetezo cha Maso
Astaxanthin ili ndi antioxidant ntchito yomwe imachepetsa ma molekyulu opanda okosijeni ndipo imateteza maso. Astaxanthin imagwira ntchito mogwirizana ndi ma carotenoids ena omwe amathandizira thanzi lamaso, makamaka lutein ndi zeaxanthin. Kuphatikiza apo, astaxanthin imachulukitsa kuchuluka kwa magazi m'maso, zomwe zimapangitsa kuti magaziwo azitulutsanso mpweya wa retina ndi minofu yamaso. Kafukufuku wawonetsa kuti astaxanthin, kuphatikiza ndi ma carotenoids ena, amateteza maso kuti asawonongeke kudera lonse la dzuwa. Kuphatikiza apo, astaxanthin imathandizira kuthetsa kusawona bwino kwamaso komanso kutopa kwamaso.
Justgood Health Blue Light Protection Softgels, Zosakaniza zazikulu: lutein, zeaxanthin, astaxanthin.
3) Kusamalira Khungu
Kupsinjika kwa okosijeni ndikofunikira kwambiri pakukalamba kwa khungu la munthu komanso kuwonongeka kwa khungu. Kachitidwe ka ukalamba wamkati (nthawi) ndi kunja (kuwala) ndiko kupanga kwa ROS, mwachilengedwe kudzera mu metabolism ya okosijeni, komanso kuchokera kunja kudzera pakukhudzidwa ndi kuwala kwa dzuwa (UV). Zochitika za okosijeni pa ukalamba wa khungu zimaphatikizapo kuwonongeka kwa DNA, kuyankhidwa kotupa, kuchepetsa ma antioxidants, ndi kupanga matrix metalloproteinases (MMPs) omwe amawononga kolajeni ndi elastin mu dermis.
Astaxanthin imatha kuletsa bwino kuwonongeka kwa okosijeni komwe kumapangidwa ndi ma radical komanso kulowetsedwa kwa MMP-1 pakhungu pambuyo pakuwonekera kwa UV. Kafukufuku wasonyeza kuti astaxanthin yochokera ku Erythrocystis rainbowensis imatha kuonjezera collagen poletsa kufotokoza kwa MMP-1 ndi MMP-3 mu dermal fibroblasts. Kuphatikiza apo, astaxanthin idachepetsa kuwonongeka kwa DNA yopangidwa ndi UV ndikuwonjezera kukonzanso kwa DNA m'maselo omwe amakumana ndi cheza cha UV.
Justgood Health pakali pano ikuchita maphunziro angapo, kuphatikiza makoswe opanda tsitsi ndi mayeso aumunthu, zonse zomwe zawonetsa kuti astaxanthin imachepetsa kuwonongeka kwa UV kukuya kwakuya kwapakhungu, komwe kumayambitsa kuoneka kwa zizindikiro za ukalamba wa khungu, monga kuuma, kufooka kwa khungu ndi khungu. makwinya.
4) Zakudya zamasewera
Astaxanthin imatha kufulumizitsa kukonzanso pambuyo pochita masewera olimbitsa thupi. Anthu akamachita masewera olimbitsa thupi kapena kuchita masewera olimbitsa thupi, thupi limapanga ROS yambiri, yomwe, ikapanda kuchotsedwa nthawi, ikhoza kuwononga minofu ndi kuwononga thupi, pamene astaxanthin amphamvu antioxidant ntchito akhoza kuchotsa ROS nthawi ndi kukonza minofu yowonongeka mofulumira.
Justgood Health imayambitsa Astaxanthin Complex yake yatsopano, yosakanikirana ndi magnesium glycerophosphate, vitamini B6 (pyridoxine), ndi astaxanthin yomwe imachepetsa kupweteka kwa minofu ndi kutopa pambuyo pochita masewera olimbitsa thupi. Fomulayi imayang'ana pa Justgood Health's Whole Algae Complex, yomwe imapereka astaxanthin yachilengedwe yomwe imateteza minofu ku kuwonongeka kwa okosijeni, komanso imapangitsa kuti minofu igwire bwino ntchito ndikuwongolera masewera olimbitsa thupi.
5) Thanzi la mtima
Kupsinjika kwa okosijeni ndi kutupa kumawonetsa pathophysiology ya atherosulinosis yamtima. Ntchito yapamwamba kwambiri ya antioxidant ya astaxanthin imatha kuteteza ndikuwongolera atherosulinosis.
Justgood Health Triple Strength Natural Astaxanthin Softgels amathandizira kukhalabe ndi thanzi lamtima pogwiritsa ntchito astaxanthin yachilengedwe yochokera ku ndere zofiira za utawaleza, zosakaniza zake zomwe zimaphatikizapo astaxanthin, mafuta a kokonati a namwali komanso tocopherols zachilengedwe.
6) Malamulo a Chitetezo cha mthupi
Maselo a chitetezo chamthupi amakhudzidwa kwambiri ndi kuwonongeka kwakukulu kwaufulu. Astaxanthin imateteza chitetezo chamthupi popewa kuwonongeka kwakukulu kwaulere. Kafukufuku adapeza kuti astaxanthin m'maselo aumunthu kuti apange ma immunoglobulins, m'thupi la munthu astaxanthin supplementation kwa masabata a 8, kuchuluka kwa astaxanthin m'magazi kumawonjezeka, maselo a T ndi maselo a B akuwonjezeka, kuwonongeka kwa DNA kumachepetsedwa, mapuloteni a C-reactive amachepetsa kwambiri.
Ma astaxanthin softgels, astaxanthin yaiwisi, amagwiritsa ntchito kuwala kwa dzuwa, madzi osefedwa ndi lava ndi mphamvu ya dzuwa kuti apange astaxanthin yoyera komanso yathanzi, yomwe ingathandize kulimbikitsa chitetezo cha mthupi, kuteteza masomphenya komanso thanzi labwino.
7) Pewani Kutopa
Kafukufuku wa masabata a 4 osasinthika, osawona kawiri, oyendetsedwa ndi placebo, njira ziwiri zodutsana anapeza kuti astaxanthin imalimbikitsa kuchira kuchokera ku zowoneka bwino (VDT) -kuchititsa kutopa kwamaganizo, kuchepetsa kuchuluka kwa plasma phosphatidylcholine hydroperoxide (PCOOH) m'maganizo ndi thupi. ntchito. Chifukwa chikhoza kukhala antioxidant ntchito ndi anti-yotupa njira ya astaxanthin.
8) Chitetezo cha chiwindi
Astaxanthin ili ndi zodzitetezera komanso zothandiza pamavuto azaumoyo monga chiwindi fibrosis, kuvulala kwachiwindi kwa ischemia-reperfusion, ndi NAFLD. Astaxanthin ikhoza kuyendetsa njira zosiyanasiyana zowonetsera, monga kuchepetsa ntchito ya JNK ndi ERK-1 kuti ipititse patsogolo kukana kwa insulini ya chiwindi, kulepheretsa PPAR-γ kufotokoza kuchepetsa kaphatikizidwe ka mafuta a chiwindi, ndi kutsika-regulating TGF-β1 / Smad3 kufotokozera kuti kuletsa kuyambitsa kwa HSCs ndi chiwindi fibrosis.
Mkhalidwe wa malamulo m'dziko lililonse
Ku China, astaxanthin kuchokera ku gwero la algae wofiira angagwiritsidwe ntchito ngati chakudya chatsopano cha chakudya (kupatula chakudya cha ana), kuphatikizapo United States, Canada ndi Japan amalola kuti astaxanthin agwiritsidwe ntchito mu chakudya .
Nthawi yotumiza: Dec-05-2024