Astaxanthin (3,3'-dihydroxy-beta,beta-carotene-4,4'-dione) ndi carotenoid, yomwe imatchedwa lutein, yomwe imapezeka m'magulu osiyanasiyana a tizilombo toyambitsa matenda ndi nyama zam'madzi, ndipo poyamba inali yosiyana ndi nkhanu za Kuhn ndi Sorensen. Ndi pigment yosungunuka mafuta yomwe imawoneka ngati lalanje mpaka yofiira kwambiri ndipo ilibe vitamini A yogwira ntchito m'thupi la munthu.
Magwero achilengedwe a astaxanthin amaphatikizapo algae, yisiti, salimoni, trout, krill ndi crayfish. Astaxanthin yamalonda imachokera ku yisiti ya Fife, algae wofiira ndi kaphatikizidwe ka mankhwala. Chimodzi mwazinthu zabwino kwambiri za astaxanthin zachilengedwe ndi chlorella yofiira yamvula, yokhala ndi astaxanthin pafupifupi 3.8% (mwa kulemera kowuma), komanso nsomba zakuthengo nazonso zimakhala zabwino za astaxanthin. Kupanga kopanga akadali gwero lalikulu la astaxanthin chifukwa cha kukwera mtengo kwa kulima kwakukulu kwa Rhodococcus rainieri. Ntchito yachilengedwe ya astaxanthin yopangidwa mwaluso ndi 50% yokha ya astaxanthin yachilengedwe.
Astaxanthin ilipo ngati stereoisomers, geometric isomers, free and esterified forms, ndi stereoisomers (3S,3'S) ndi (3R,3'R) kukhala ochuluka kwambiri m'chilengedwe. Rhodococcus rainieri imapanga (3S,3'S) -isomer ndi Fife yeast imapanga (3R,3'R) -isomer.
Astaxanthin, kutentha kwa mphindi
Astaxanthin ndiye gawo la nyenyezi muzakudya zogwira ntchito ku Japan.Ziwerengero za FTA pazolengeza za chakudya chogwira ntchito ku Japan mu 2022 zidapeza kuti astaxanthin idayikidwa pa nambala 7 pakati pa zopangira 10 zomwe zimagwiritsidwa ntchito pafupipafupi, ndipo zidagwiritsidwa ntchito makamaka m'magawo azaumoyo a skincare, chisamaliro chamaso, mpumulo wotopa, komanso kusintha kwa chidziwitso.
Pa 2022 ndi 2023 Asian Nutritional Ingredients Awards,Justgood Health's zachilengedwe za astaxanthin zidadziwika kuti ndizopanga bwino kwambiri pachaka kwa zaka ziwiri zotsatizana, chophatikizira chabwino kwambiri pazidziwitso zachidziwitso mu 2022, komanso chophatikizira chabwino kwambiri panjira yokongola yapakamwa mu 2023. Kuphatikiza apo, chophatikiziracho chidasankhidwa mumpikisano wa Asian Nutritional Ingredients 4 track - Health2y Aging02.
M'zaka zaposachedwa, kafukufuku wamaphunziro a astaxanthin wayambanso kutentha. Malinga ndi data ya PubMed, koyambirira kwa 1948, panali maphunziro a astaxanthin, koma chidwi chakhala chochepa, kuyambira mu 2011, maphunziro adayamba kuyang'ana kwambiri astaxanthin, ndi zofalitsa zopitilira 100 pachaka, ndi zopitilira 200 mu 2017, zopitilira 300 mu 2020, ndi zopitilira 2020.
Gwero la chithunzi:PubMed
Pankhani ya msika, malinga ndi zidziwitso za msika wamtsogolo, kukula kwa msika wa astaxanthin padziko lonse lapansi kukuyembekezeka kukhala $ 273.2 miliyoni mu 2024 ndipo akuyembekezeka kufika $ 665.0 miliyoni pofika 2034, pa CAGR ya 9.3% panthawi yolosera (2024-2034).
Mphamvu yapamwamba ya antioxidant
Mapangidwe apadera a Astaxanthin amamupatsa mphamvu ya antioxidant. Astaxanthin ili ndi ma conjugated double bond, hydroxyl ndi ketone magulu, ndipo onse ndi lipophilic ndi hydrophilic. The conjugated double bond pakatikati pa pawiri amapereka ma elekitironi ndi amachita ndi ma radicals ufulu kuwasandutsa zinthu khola kwambiri ndi kuthetseratu ufulu ankafuna kusintha chain zochita mu zamoyo zosiyanasiyana. Ntchito yake yachilengedwe ndiyopambana kuposa ya ma antioxidants ena chifukwa chotha kulumikizana ndi nembanemba zama cell kuchokera mkati kupita kunja.
Malo a astaxanthin ndi ma antioxidants ena m'maselo a cell
Astaxanthin imakhala ndi ntchito yayikulu yoteteza antioxidant osati kungowononga mwachindunji ma radicals aulere, komanso kudzera mu kuyambitsa ma cell antioxidant system powongolera njira ya nyukiliya erythroid 2-related factor (Nrf2). Astaxanthin imalepheretsa mapangidwe a ROS ndikuwongolera mawonetseredwe a ma enzymes omwe amakhudzidwa ndi oxidative, monga heme oxygenase-1 (HO-1), yomwe ndi chizindikiro cha kupsinjika kwa okosijeni.HO-1 imayendetsedwa ndi zinthu zosiyanasiyana zolembera zovuta, kuphatikizapo Nrf2, yomwe imamangiriza ku antioxidant-responsive elements in the antioxidant-responsive elements in the antioxidant-responsive elements in the antioxidant-responsive elements in the antioxidant-responsive factors
Ubwino wathunthu wa astaxanthin ndi kugwiritsa ntchito
1) Kupititsa patsogolo chidziwitso cha ntchito
Kafukufuku wambiri watsimikizira kuti astaxanthin imatha kuchedwetsa kapena kuwongolera kuperewera kwachidziwitso komwe kumayenderana ndi ukalamba wabwinobwino kapena kuchepetsa ma pathophysiology amatenda osiyanasiyana a neurodegenerative. Astaxanthin imatha kuwoloka chotchinga chamagazi-muubongo, ndipo kafukufuku wasonyeza kuti zakudya za astaxanthin zimadziunjikira mu hippocampus ndi cerebral cortex ya ubongo wa makoswe pambuyo podya kamodzi komanso mobwerezabwereza, zomwe zingakhudze kukonza ndi kuwongolera kwa chidziwitso. Astaxanthin imalimbikitsa kusinthika kwa maselo a mitsempha ndikuwonjezera jini ya glial fibrillary acidic protein (GFAP), mapuloteni otchedwa microtubule 2 (MAP-2), ubongo-derived neurotrophic factor (BDNF), ndi mapuloteni okhudzana ndi kukula kwa 43 (GAP-43), mapuloteni omwe amakhudzidwa ndi ubongo.
Makapisozi a Justgood Health Astaxanthin, okhala ndi Cytisine ndi Astaxanthin ochokera ku Red Algae Rainforest, amalumikizana kuti apititse patsogolo kuzindikira kwa ubongo.
2) Chitetezo cha Maso
Astaxanthin ili ndi antioxidant ntchito yomwe imachepetsa ma molekyulu opanda okosijeni ndipo imateteza maso. Astaxanthin imagwira ntchito mogwirizana ndi ma carotenoids ena omwe amathandizira thanzi lamaso, makamaka lutein ndi zeaxanthin. Kuphatikiza apo, astaxanthin imachulukitsa kuchuluka kwa magazi m'maso, zomwe zimapangitsa kuti magaziwo azitulutsanso mpweya wa retina ndi minofu yamaso. Kafukufuku wawonetsa kuti astaxanthin, kuphatikiza ndi ma carotenoids ena, amateteza maso kuti asawonongeke kudera lonse la dzuwa. Kuphatikiza apo, astaxanthin imathandizira kuthetsa kusawona bwino kwamaso komanso kutopa kwamaso.
Justgood Health Blue Light Protection Softgels, Zosakaniza zazikulu: lutein, zeaxanthin, astaxanthin.
3) Kusamalira Khungu
Kupsinjika kwa oxidative ndichinthu chofunikira kwambiri pakukalamba kwa khungu la munthu komanso kuwonongeka kwa khungu. Kachitidwe ka ukalamba wamkati (nthawi) ndi kunja (kuwala) ndiko kupanga kwa ROS, mwachilengedwe kudzera mu metabolism ya okosijeni, komanso kuchokera kunja kudzera pakukhudzidwa ndi kuwala kwa dzuwa (UV). Zochitika za okosijeni pa ukalamba wa khungu zimaphatikizapo kuwonongeka kwa DNA, kuyankhidwa kotupa, kuchepetsa ma antioxidants, ndi kupanga matrix metalloproteinases (MMPs) omwe amawononga kolajeni ndi elastin mu dermis.
Astaxanthin imatha kuletsa bwino kuwonongeka kwa okosijeni komwe kumapangidwa ndi ma radical komanso kulowetsedwa kwa MMP-1 pakhungu pambuyo pakuwonekera kwa UV. Kafukufuku wasonyeza kuti astaxanthin yochokera ku Erythrocystis rainbowensis imatha kuonjezera collagen poletsa kufotokoza kwa MMP-1 ndi MMP-3 mu dermal fibroblasts. Kuphatikiza apo, astaxanthin idachepetsa kuwonongeka kwa DNA yopangidwa ndi UV ndikuwonjezera kukonza kwa DNA m'maselo omwe amakumana ndi ma radiation a UV.
Justgood Health pakali pano ikuchita maphunziro angapo, kuphatikiza makoswe opanda tsitsi ndi mayeso aumunthu, zonse zomwe zawonetsa kuti astaxanthin imachepetsa kuwonongeka kwa UV ku zigawo zakuya zapakhungu, zomwe zimapangitsa kuoneka kwa zizindikiro za ukalamba wa khungu, monga kuuma, kufota khungu ndi makwinya.
4) Zakudya zamasewera
Astaxanthin imatha kufulumizitsa kukonzanso pambuyo pochita masewera olimbitsa thupi. Anthu akamachita masewera olimbitsa thupi kapena kuchita masewera olimbitsa thupi, thupi limapanga ROS yambiri, yomwe, ikapanda kuchotsedwa nthawi, ikhoza kuwononga minofu ndi kuwononga thupi, pamene astaxanthin amphamvu antioxidant ntchito akhoza kuchotsa ROS nthawi ndi kukonza minofu yowonongeka mofulumira.
Justgood Health imayambitsa Astaxanthin Complex yake yatsopano, yosakanikirana ndi magnesium glycerophosphate, vitamini B6 (pyridoxine), ndi astaxanthin yomwe imachepetsa kupweteka kwa minofu ndi kutopa pambuyo pochita masewera olimbitsa thupi. Fomulayi imayang'ana pa Justgood Health's Whole Algae Complex, yomwe imapereka astaxanthin yachilengedwe yomwe imateteza minofu ku kuwonongeka kwa okosijeni, komanso imapangitsa kuti minofu igwire bwino ntchito ndikuwongolera masewera olimbitsa thupi.
5) Thanzi la mtima
Kupsinjika kwa okosijeni ndi kutupa kumawonetsa pathophysiology ya atherosulinosis yamtima. Ntchito yapamwamba kwambiri ya antioxidant ya astaxanthin imatha kuteteza ndikuwongolera atherosulinosis.
Justgood Health Triple Strength Natural Astaxanthin Softgels amathandizira kukhalabe ndi thanzi lamtima pogwiritsa ntchito astaxanthin yachilengedwe yochokera ku ndere zofiira za utawaleza, zosakaniza zake zomwe zimaphatikizapo astaxanthin, mafuta a kokonati a namwali komanso tocopherols zachilengedwe.
6) Malamulo a Chitetezo cha mthupi
Maselo a chitetezo chamthupi amakhudzidwa kwambiri ndi kuwonongeka kwakukulu kwaufulu. Astaxanthin imateteza chitetezo chamthupi popewa kuwonongeka kwakukulu kwaulere. Kafukufuku adapeza kuti astaxanthin m'maselo aumunthu kuti apange ma immunoglobulins, m'thupi la munthu astaxanthin supplementation kwa masabata a 8, kuchuluka kwa astaxanthin m'magazi kumawonjezeka, maselo a T ndi maselo a B akuwonjezeka, kuwonongeka kwa DNA kumachepetsedwa, mapuloteni a C-reactive amachepetsa kwambiri.
Ma astaxanthin softgels, astaxanthin yaiwisi, amagwiritsa ntchito kuwala kwa dzuwa, madzi osefedwa ndi lava ndi mphamvu ya dzuwa kuti apange astaxanthin yoyera komanso yathanzi, yomwe ingathandize kulimbikitsa chitetezo cha mthupi, kuteteza masomphenya komanso thanzi labwino.
7) Pewani Kutopa
Kafukufuku wa 4-sabata wosasinthika, wakhungu, wakhungu, woyendetsedwa ndi placebo, njira ziwiri zodutsamo adapeza kuti astaxanthin imalimbikitsa kuchira kuchokera ku kutopa kwamaganizidwe (VDT) -kuchititsa kutopa kwamalingaliro, kuchepetsa kuchuluka kwa plasma phosphatidylcholine hydroperoxide (PCOOH) pazochitika zonse zamaganizidwe komanso zolimbitsa thupi. Chifukwa chikhoza kukhala antioxidant ntchito ndi anti-yotupa njira ya astaxanthin.
8) Chitetezo cha chiwindi
Astaxanthin imakhala ndi zodzitetezera komanso zothandiza pamavuto azaumoyo monga chiwindi fibrosis, kuvulala kwachiwindi kwa ischemia-reperfusion, ndi NAFLD. Astaxanthin ikhoza kuyendetsa njira zosiyanasiyana zowonetsera zizindikiro, monga kuchepetsa ntchito ya JNK ndi ERK-1 kuti apititse patsogolo insulini ya hepatic kukana, kulepheretsa PPAR-γ kufotokoza kuti kuchepetsa kaphatikizidwe ka mafuta a chiwindi, ndi kutsika-regulating TGF-β1 / Smad3 kufotokozera kuti kulepheretsa HSCs kutsegula ndi fibrosis ya chiwindi.
Mkhalidwe wa malamulo m'dziko lililonse
Ku China,astaxanthin kuchokera ku gwero la utawaleza wofiira algae angagwiritsidwe ntchito monga chakudya chatsopano pophika chakudya ambiri (kupatula chakudya mwana), komanso, United States, Canada ndi Japan komanso kulola astaxanthin ntchito chakudya .
Nthawi yotumiza: Dec-05-2024