Mphamvu ya anthu amakono ikuchepa pang'onopang'ono.
Kuchokera pa “woyambitsa mavuto akudzuka msanga” mpaka “kudzaza ndi khofi nthawi ya 3 koloko madzulo”, kuyambira pa “kukumbukira zinthu” mpaka “kutopa kwambiri mutatha kuchita masewera olimbitsa thupi” – “kuchepa kwa mphamvu” sikulinso chizindikiro cha okalamba okha; achinyamata ambiri ndi ogwira ntchito m'maofesi nawonso akukhudzidwa kwambiri ndi izi. Ndi kufulumira kwa moyo wamakono, chiwerengero cha anthu omwe akuvutika ndi kutopa ndi kusowa mphamvu chikuchulukirachulukira padziko lonse lapansi. Poyang'anizana ndi “vuto la mphamvu” ili, njira zambiri zothanirana ndi vutoli ndi kungolimbikitsa kwakanthawi kochepa ndi caffeine ndi mphamvu kwakanthawi, koma zimangothetsa zizindikiro, osati chomwe chimayambitsa. Ndiye, kodi pali chinthu chomwe chingathetse vutoli lomwe lili muzu wa kagayidwe ka mphamvu m'maselo?
PQQ (pyrroloquinoline quinone) ikupereka yankho. Kumvetsetsa PQQ: Gwero ndi Kapangidwe kake PQQ imapezeka kwambiri m'chilengedwe, ndi zinthu zachilengedwe kuphatikizapo natto, tiyi wobiriwira, tsabola wobiriwira, kiwis, mapapaya, sipinachi, ndi zina zotero. Komabe, kuchuluka kwa PQQ mu zakudya zachilengedwezi n'kochepa kwambiri. Potengera natto yopangidwa ndi soya yovunditsidwa mwachitsanzo, kuchuluka kwakukulu komwe kumaganiziridwa ndi 61 yokha.±Ma nanogram 31 pa gramu imodzi ya kulemera konyowa. Chifukwa chake, PQQ yomwe imapezeka pamsika siichokera mwachindunji ku zakudya zachilengedwe. Njira yodziwika bwino yopangira ndi kuwiritsa tizilombo toyambitsa matenda: kudzera mu kuwiritsa ndi Methanomonas, Acinetobacter, ndi Gluconobacter, kenako ndikulekanitsa ndi kuyeretsa kuchokera ku madzi owiritsa kuti mupeze PQQ yomalizidwa bwino kwambiri. Njirayi ili ndi ndalama zowongolera komanso chiyero chokhazikika, ndipo ndiyo njira yodziwika bwino yamakampani.
Chitsime: Pexels
Fomula ya mankhwala ya PQQ ndi 4,5-dicarbonyl-1-pyrrolo-2,3-f-quinolin-2,7,9-tricarboxylic acid, yokhala ndi fomula ya molekyulu ya C14H6N2O8, ndi kulemera kwa molekyulu ya 330.21. Imaonedwa ngati vitamini B, kukhala coenzyme yachitatu ya oxidoreductase yomwe imapezeka mu mabakiteriya pambuyo pa nicotinamide adenine dinucleotide ndi flavin adenine dinucleotide, kupatula apo, ndi mtundu wachitatu wa coenzyme mu ma enzyme osinthira ma electron. Ponena za kapangidwe ka mankhwala, PQQ ili ndi magulu atatu a carboxyl omwe amatha kumangirira ku mapuloteni, ndi magulu awiri a ketone omwe amagwira ntchito mu mphamvu yochepetsera okosijeni ya molekyulu. Ili ndi kusungunuka kwabwino kwa madzi ndikugwirizana ndi zamoyo, imatha kukhalapo m'thupi mu mawonekedwe a ionic, ndipo imatha kuyamwa bwino ndi maselo ndikuchita nawo machitidwe a kagayidwe kachakudya. Kuphatikiza apo, PQQ imawoneka ngati makhiristo ofiira-bulauni, okhala ndi mfundo ya isoelectric ya 2.75 ndi mfundo yosungunuka ya 250.°C.
Chitsime: Buku Lofotokozera [4]
PQQ: "Energy Manager" ya Thupi la Munthu PQQ imayambira kuchokera ku gwero la mphamvu ya maselo - mitochondria, ndipo sikuti imangokonza ndi kubwezeretsa mitochondria, komanso imathandizira kupirira kwa minofu ndikukulitsa kuganiza kwa ubongo, kuyang'anira bwino mphamvu za munthu, ndipo imatha kutchedwa "energy manager" ya thupi la munthu.
1) Kukonza ndi kukonzanso mitochondria - kulimbitsa maziko a kupanga mphamvu zamaselo Mitochondria ndi "fakitale yamphamvu" ya maselo, ndipo 95% ya mphamvu ya thupi imachokera ku mitochondria, ndipo kusagwira bwino ntchito kwa mitochondria kumakhudzana ndi 80% ya kukalamba. Kupadera kwa PQQ kuli m'chakuti sikuti kungokonza mitochondria yowonongeka komanso kulimbikitsa kupanga mitochondria yatsopano, yomwe ilibe zinthu zachikhalidwe monga vitamini E ndi coenzyme Q10. Ponena za kukonza, gulu lofufuza kuchokera ku University of California, USA, mu 2013 linapeza kuti akuluakulu athanzi omwe adawonjezera 20mg ya PQQ tsiku lililonse adawonetsa kusintha kwakukulu mu magwiridwe antchito a ATP synthesis ndi antioxidant enzyme patatha masiku atatu okha; mu 2023, "Cell Death Dis" idavumbulutsanso kuti PQQ imatha kuchotsa mitochondria yowonongeka ndikuwonjezera autophagy ya mitochondria, kulola fakitale yamphamvu kuyambiranso kugwira ntchito bwino. Pamlingo wobwezeretsa, PQQ imalimbikitsa mwachindunji biosynthesis ya mitochondria yatsopano poyambitsa njira zazikulu zolumikizirana monga PGC-1α, motero kumawonjezera kuchuluka ndi ubwino wa mitochondria komwe imachokera komanso kupititsa patsogolo ntchito yopereka mphamvu m'maselo.
2) Kulimbitsa kupirira kwa minofu - Kulimbitsa malire apamwamba a kupirira kwa masewera olimbitsa thupi. Pambuyo pa masewera olimbitsa thupi, pamakhala kupweteka kwa minofu kosalekeza, komwe kwenikweni ndi kuwonongeka komwe kumachitika chifukwa cha ma free radicals omwe amapangidwa chifukwa cha ntchito yambiri ya mitochondrial, zomwe zimapangitsa kuti "minofu itope". Ntchito zamphamvu zotsutsana ndi kutupa za PQQ zimagwira ntchito yofunika kwambiri pano. Zingathe kuchepetsa mwachindunji kuwonongeka kwa minofu komwe kumachitika chifukwa cha masewera olimbitsa thupi, motero zimalimbitsa kupirira kwa minofu ndikufupikitsa nthawi yochira. Kafukufuku mu 2019 wokhudza amuna 23 adawonetsa kuti pambuyo powonjezera 20mg PQQ tsiku lililonse ndi masabata 6 a maphunziro, chinthu chachikulu chomwe chimalamulira kupanga mitochondrial, PGC-1α, yawonjezeka kuchoka pa 4.59 ng/mg kufika pa 10.42 ng/mg, pomwe gulu la placebo linangowonjezeka kuchoka pa 3.95 ng/mg kufika pa 5.55 ng/mg. Kuwonjezeka kwakukulu kumeneku kumatanthauza kuti PQQ imayambitsa PGC-1α njira yolumikizirana, imalimbikitsa kupanga mitochondria yatsopano mkati mwa maselo a minofu, imakonza kagayidwe ka mphamvu, ndipo imapereka ATP yokwanira yochitira masewera olimbitsa thupi mosalekeza. Kuyesa kwa nyama kwatsimikiziranso kuti kuwonjezera PQQ kungathandize minofu ya minofu kukonzanso mwachangu mwa kuchotsa ma free radicals ndikuletsa NF-κMayankho otupa omwe amayambitsidwa ndi B, motero amalimbitsa kupirira kwa minofu ndikuchepetsa bwino kutopa kwa minofu ndi kuvulala kwa masewera olimbitsa thupi.
3) Kulimbitsa kuganiza kwa ubongo - Lankhulani bwino ndi chifunga cha ubongo ndi kuchedwa Kuchepa kwa chidziwitso si vuto la okalamba okha. Deta yochokera ku "Blue Book of Alzheimer's Disease in China" ikuwonetsa kuti kufalikira kwa kuchepa kwa chidziwitso pakati pa okalamba ndi 46.4%, ndipo magulu ogwiritsa ntchito ubongo mwamphamvu monga ophunzira ndi opanga mapulogalamu nawonso amakumana ndi kuganiza mochedwa. Kuyesa kwa achinyamata mu 2023 mu "Food & Function" kunapeza kuti pambuyo powonjezera 20mg PQQ tsiku lililonse kwa masabata 8, kusinthasintha kwa chidziwitso, liwiro la kukonza, ndi liwiro la kuchitapo kanthu kwa gulu la zaka 20-40 kunali bwino kwambiri kuposa gulu la placebo, ndipo zitha kudziwika 100% ngati adawonjezera PQQ. Mu kafukufukuyu, zigoli zapakati pa Montreal Cognitive Assessment Scale (MoCA) za anthu omwe adaphunzira zidakwera ndi mfundo 4, zomwe zikusonyeza kusintha kwakukulu m'magawo ofunikira a chidziwitso monga chidwi, kukumbukira, ndi luso la chilankhulo. Kafukufukuyu akuwonetsa kuti PQQ imatha kudutsa chotchinga cha magazi muubongo, kuchepetsa mitundu ya okosijeni yogwira ntchito muubongo, kuyambitsa njira zotsutsana ndi kutupa, ndikulimbikitsa kupanga zinthu za neurotrophic, potero kuteteza ndikuthandizira kukula kwa maselo amitsempha.
Kuvomerezedwa kwa PQQ padziko lonse lapansi. Padziko lonse lapansi, PQQ yadziwika ndi mabungwe angapo odalirika motsatizana.
Chitsime: European Commission
Ku China, National Health Commission idavomereza kukonzekera kwa mchere wa PQQ disodium monga chowonjezera chatsopano cha chakudya mu 2022, kenako mu 2023, kukonzekera kwa mchere wa PQQ disodium kunavomerezedwa ngati chowonjezera chatsopano cha chakudya.
Malinga ndi Bo Yan Zhixiang, pofika chaka cha 2025, kukula kwa msika wa PQQ ku China kudzafika pa 960 miliyoni yuan, ndi kukula kwa chaka ndi chaka kwa 20.0%, kwakukulu kwambiri kuposa kukula kwapakati padziko lonse kwa 14.3%. Zikuyembekezeka kuti mu 2026, kukula kwa msika wa PQQ ku China kudzafika pa 1.152 biliyoni yuan, kuwonjezeka kwa 20.0% poyerekeza ndi 2025, kupitiliza kukula kwakukulu. PQQ ili ndi mitundu yosiyanasiyana ya njira zogwiritsira ntchito, ndipo ikhoza kuphatikizidwa ndi spermidine, inositol, ndi zina zotero, zomwe zikuphatikizapo njira zotsutsana ndi ukalamba, chitetezo cha chiwindi, ndi thanzi la ubongo. Kuphatikiza apo, m'zaka zaposachedwa, PQQ yatulutsanso zinthu zopangira zodzikongoletsera, kukulitsa kugwiritsidwa ntchito kwake kumakampani okongoletsa. Kwa ofufuza, PQQ, ndi kafukufuku wolimba wamakina, mwayi wopeza malamulo m'maiko ambiri, komanso msika wokulirapo, ikusintha pang'onopang'ono kuchoka pa chinthu chodziwika bwino kupita ku michere yofunika kwambiri yanthawi yayitali.
1) Kuchokera ku kugawa kwa madera padziko lonse lapansi, zinthu za PQQ ku North America ndi Europe zimayang'ana kwambiri pakuwonjezera mphamvu, thanzi la ubongo, komanso kuletsa ukalamba. Kapisozi ya PQQ yomwe idayambitsidwa ndi kampani yaku China ya Health Nova, gawo lake lalikulu ndi mchere wa PQQ disodium, ndipo kapisozi iliyonse ili ndi 20mg, imati imalimbikitsa kukula kwa mitochondria.
Nthawi yotumizira: Juni-30-2026